International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes 1989-01-01

An improved HPLC system for the analysis and purification of organic amine radiopharmaceuticals.

M J Adam, J R Grierson, S Jivan

Index: Appl. Radiat. Isot. 40 , 91-92, (1989)

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Abstract

This paper describes the separation of lipophilic amine radiopharmaceuticals on normal phase silica using a reversed phase type eluant. This class of compound usually gives very poor peak symmetry on reversed phase columns. However, excellent separation of a number of amines of interest to Positron Emission Tomography, such as spiperone and its derivatives, has been achieved on this system.