Chinese Chemical Letters

Efficient synthesis of functionalized 1, 3-dihydroisobenzofurans from salicylaldehydes: Application to the synthesis of escitalopram

P Wang, R Zhang, J Cai, JQ Chen, M Ji

Index: Wang, Peng; Zhang, Rui; Cai, Jin; Chen, Jun-Qing; Ji, Min Chinese Chemical Letters, 2014 , vol. 25, # 4 p. 549 - 552

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Citation Number: 3

Abstract

Abstract An efficient synthesis of substituted 1, 3-dihydroisobenzofurans is developed. In this novel route, o-aroylbenzaldehydes, as key intermediates, can be obtained by lead tetraacetate oxidation of N-aroylhydrazones of salicylaldehydes. The mild and general strategy enables the synthesis of various substituted 1, 3-dihydroisobenzofurans in high yields. Moreover, this method can be applied to efficiently synthesize escitalopram.