Direct substitution of hydroxyl groups of allyl alcohols with alkyl groups by the reaction of lithium allyloxyalkylcuprates with N, N- …

Y Tanigawa, H Kanamaru, A Sonoda…

Index: Tanigawa,Y. et al. Journal of the American Chemical Society, 1977 , vol. 99, p. 2361 - 2363

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Citation Number: 38

Abstract

The allylic unit'is a common structural feature of many compounds of natural origin, and the most important synthon for such units are allyl alcohols. We wish now to report a novel and efficient method for direct substitution of a hydroxyl group of alcohols with alkyl or aryl groups of the corresponding or-ganolithium compounds in a single step as depicted in eq 1. The reaction appears to be general and particularly efficient for regio-and stereoselective ...