Tetrahedron

Preparation d'acides β-amino-ethyl-phosphoniques

J Blanchard, N Collignon, P Savignac, H Normant

Index: Blanchard,J. et al. Tetrahedron, 1976 , vol. 32, p. 455 - 459

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Citation Number: 30

Abstract

We describe a new, practical, synthesis of β-amino ethyl phosphonic acids. Organolithium reagents generated from nitriles are condensed with bis (dimethyl amino) chlorophosphates, followed by alkylation using phase transfer catalysis, reduction of nitrile group, and acid hydrolysis.