Comparative pharmacokinetics and pharmacodynamics after subcutaneous and intramuscular administration of medroxyprogesterone acetate (25 mg) and estradiol cypionate (5 mg)

José Alfredo Sierra-Ramírez, Roger Lara-Ricalde, Miguel Lujan, Norma Velázquez-Ramírez, Marycarmen Godínez-Victoria, Ivonne Araceli Hernádez-Munguía, Agustin Padilla, Josué Garza-Flores, José Alfredo Sierra-Ramírez, Roger Lara-Ricalde, Miguel Lujan, Norma Velázquez-Ramírez, Marycarmen Godínez-Victoria, Ivonne Araceli Hernádez-Munguía, Agustin Padilla, Josué Garza-Flores

Index: Contraception 84(6) , 565-70, (2011)

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Abstract

Background The efficacy of contraceptives is affected by its route and ease of administration. Herein, both pharmacokinetics and pharmacodynamics of the once-a-month combined injectable contraceptive medroxyprogesterone acetate (MPA) plus estradiol cypionate (E 2-Cyp) were compared after intramuscular (IM) or subcutaneous (SC) injection in women of reproductive age.