Molecules

Large-scale solvent-free chlorination of hydroxy-pyrimidines,-pyridines,-pyrazines and-amides using equimolar POCl3

H Wang, K Wen, L Wang, Y Xiang, X Xu, Y Shen, Z Sun

Index: Wang, Han; Wen, Kun; Wang, Le; Xiang, Ye; Xu, Xiaocheng; Shen, Yongjia; Sun, Zhihua Molecules, 2012 , vol. 17, # 4 p. 4533 - 4544

Full Text: HTML

Citation Number: 15

Abstract

Abstract: Chlorination with equimolar POCl 3 can be efficiently achieved not only for hydroxypyrimidines, but also for many other substrates such as 2-hydroxy-pyridines,- quinoxalines, or even-amides. The procedure is solvent-free and involves heating in a sealed reactor at high temperatures using one equivalent of pyridine as base. It is suitable for large scale (multigram) batch preparations.