Efficient synthesis of furochromone and furocoumarin natural products (khellin, pimpinellin, isophellopterin) by thermal rearrangement of 4-furyl-4- …

MW Reed, HW Moore

Index: Reed, Michael W.; Moore, Harold W. Journal of Organic Chemistry, 1988 , vol. 53, # 8 p. 4166 - 4171

Full Text: HTML

Citation Number: 32

Abstract

Background Most recent synthetic efforts toward khellin have been directed at its benzofuran precursor khellinone (9P since it can be converted to khellin in 85% yield by a Claisen-like condensation with ethyl acetate, followed by acid-catalyzed cyclization and dehydration. & Khellinone has the further advantage that it can be converted to khellin analogues when substituted acetates are used in the condensationa2 Historically, construction of the fully ...