Neoplasma 1986-09-01

Cytotoxic and mutagenic in vitro effect of 7-O-epoxyalkyl derivatives of daunomycinone. Part IX.

M Sturd__kov_, A Fuskov_, V Prikrylov_, M Podojil, J Fuska

Index: Neoplasma 33(3) , 297-305, (1986)

Full Text: HTML

Abstract

The cytotoxic effect of (7S)- and (7R)-O-epoxyalkyl derivatives of daunomycinone on leukemia P388 cells was followed in in vitro tests and their mutagenicity was determined by means of the bacterial SOS chromotest. The biological effects of the substances were compared with those of daunomycin, carminomycin and nogalamycin. The most efficient derivative proved to be the (7S)-9-acetyl-4-methoxy 7-O-(2,3-epoxypropyl)-7,8,9,10-tetrahydro-6,9,11-trihydroxy-5, 12-naphthacenequinone 10 which inhibited the DNA and RNA synthesis and proliferation of P388 cells on the level of daunomycin or carminomycin. The cytotoxic and mutagenic action of 7-O-epoxyalkyl derivatives of daunomycinone was affected by the length of alkyl and its configuration.

Related Compounds

Related Articles:

Semiquinone free radical formation by daunorubicin aglycone incorporated into the cellular membranes of intact Chinese hamster ovary cells.

1996-01-01

[Free Radic. Res. 24(1) , 9-18, (1996)]

Biotransformation of aklanonic acid by blocked mutants of anthracycline-producing strains of Streptomyces galilaeus and Streptomyces peucetius.

1986-01-01

[J. Basic Microbiol. 26(4) , 249-55, (1986)]

Synthesis and biological activity of (7S)-O-epoxyalkyl derivatives of daunomycinone.

1985-12-01

[J. Antibiot. 38(12) , 1714-8, (1985)]

Synthesis and cytotoxic activity of a new potent daunomycinone derivative.

2002-12-16

[Bioorg. Med. Chem. Lett. 12(24) , 3505-7, (2002)]

Method for analysis, and distribution profile, of covalently-linked ferritin-daunorubicin conjugate in the blood of trypanosome-infected mice.

1992-01-01

[J. Pharm. Pharmacol. 44(1) , 48-51, (1992)]

More Articles...