Isolation of flavonoids and a chalcone from Helichrysum odoratissimum and synthesis of helichrysetin.

L Van Puyvelde, N De Kimpe, J Costa, V Munyjabo, S Nyirankuliza, E Hakizamungu, N Schamp

Index: J. Nat. Prod. 52(3) , 629-33, (1989)

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Abstract

3,5-Dihydroxy-6,7,8-trimethoxyflavone, 3-O-methylquercetin, and helichrysetin were isolated from the flowers of the Rwandese medicinal plant, Helichrysum odoratissimum. Because of inconsistencies of the mp of the latter chalcone, a synthesis of helichrysetin was developed. 3-O-Methylquercetin was shown to be an active principle as it displayed antimicrobial activity.