Synthesis of potential Rho-kinase inhibitors based on the chemistry of an original heterocycle: 4,4-Dimethyl-3,4-dihydro-1H-quinolin-2-one
Marie-Anne Letellier, Jérôme Guillard, Daniel-Henri Caignard, Gilles Ferry, Jean A. Boutin, Marie-Claude Viaud-Massuard, Marie-Anne Letellier, Jérôme Guillard, Daniel-Henri Caignard, Gilles Ferry, Jean A. Boutin, Marie-Claude Viaud-Massuard
Index: Eur. J. Med. Chem. 43(8) , 1730-6, (2008)
Full Text: HTML
Abstract
A new series of substituted 4,4-dimethyl-3,4-dihydro-1 H-quinolin-2-one have been prepared via condensation of 3,3-dimethylacryloyl chloride with aniline. Details of synthetic procedures are shown. Our aim was to investigate the potency of our original heterocycle in the inhibition of the Rho-kinase enzyme, known to be of major importance in the cascade reactions leading to arterial hypertension. Biological activity for the seven compounds has been investigated and is presented.
Related Compounds
Related Articles:
2014-07-01
[Pestic. Biochem. Physiol. 113 , 55-61, (2014)]
Reaction of silylketene acetals with 3, 3-dimethylacryloyl chloride. Rousseau G and Blanco L.
[Tetrahedron Lett. 26(35) , 4195-96, (1985)]
Structure and Biosynthesis of Chrysophysarin A, a Plasmodial Pigment from the Slime Mould Physarum polycephalum (Myxomycetes). Eisenbarth S and Steffan B.
[Tetrahedron 56(3) , 363-365, (2000)]