Inhibition of adhesion molecule expression by N-alkylthiopyridine-benzo [b] thiophene-2-carboxamides

DH Boschelli, DT Connor, ME Lesch…

Index: Boschelli, Diane H.; Connor, David T.; Lesch, Mark E.; Schrier, Denis J. Bioorganic and Medicinal Chemistry, 1996 , vol. 4, # 4 p. 557 - 562

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Citation Number: 14

Abstract

The surface levels of ICAM-1 and E-selectin on activated endothelial cells can be reduced by 3-alkoxybenzo [b] thiophene-2-carboxamides. This property is shared by several N- alkylthiopyridine substituted imides. Combining structural elements of these two diverse series lead to a new class of small molecule inhibitors of adhesion molecule expression.