Design, synthesis, docking study and biological evaluation of some novel tetrahydrochromeno [3′, 4′: 5, 6] pyrano [2, 3-b] quinolin-6 (7H)-one derivatives against …

M Khoobi, M Alipour, A Moradi, A Sakhteman…

Index: Khoobi, Mehdi; Alipour, Masoumeh; Moradi, Alireza; Sakhteman, Amirhossein; Nadri, Hamid; Razavi, Seyyede Faeze; Ghandi, Mehdi; Foroumadi, Alireza; Shafiee, Abbas European Journal of Medicinal Chemistry, 2013 , vol. 68, p. 291 - 300

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Citation Number: 24

Abstract

Abstract Novel hybrid derivatives of two known scaffolds; tetrahydroaminoquinoline and coumarin were synthesized and evaluated for both acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) activities. By means of an efficient nanocatalyst, the reaction time for the syntheses of the target compounds was reduced. Subsequently, Ellman's modified method was used to evaluate the enzyme inhibitory activity of the synthesized ...