Bioconjugate chemistry

Chemical and enzyme-assisted syntheses of norbuprenorphine-3-β-D-glucuronide

J Fan, SM Brown, Z Tu, ED Kharasch

Index: Fan, Jinda; Brown, Sarah M.; Tu, Zhude; Kharasch, Evan D. Bioconjugate Chemistry, 2011 , vol. 22, # 4 p. 752 - 758

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Citation Number: 11

Abstract

Norbuprenorphine-3-β-d-glucuronide (nBPN-3-β-dG, 1) is a major phase II metabolite of buprenorphine, a pharmaceutical used for the treatment of opioid addiction. The pharmacological activity of compound 1 is not clear because investigations have been limited by the lack of chemically pure, well characterized 1 in sufficient quantities for in vitro and in vivo experiments. This work describes two concise, new methods of synthesis of 1, ...