Association of MSX1 799 G>T variant with nonsyndromic cleft lip/palate in South Indian adolescent patients.

Varun P Singh, Dinesh Ramu

Index: Int. J. Paediatr. Dent. 22(3) , 228-31, (2012)

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Abstract

Nonsyndromic cleft lip/palate (NSCLP) is a common congenital anomaly with significant medical, psychological, social, and economic ramifications. It is an example of complex genetic trait. There is sufficient evidence to hypothesise that disease locus for this condition can be identified by candidate genes. The purpose of this study was to test whether MSX1 (799 G>T) gene variant was involved in the aetiology of NSCLP.Blood samples were collected with informed consent from 25 subjects having NSCLP and 25 controls. Genomic DNA was extracted from the blood samples, polymerase chain reaction was performed (PCR), and digestion products were evaluated.The results showed a positive correlation between MSX1 (799 G>T) gene variant and NSCLP patients.MSX1 (799 G>T) gene variants may be a good screening marker for NSCLP.© 2011 The Authors. International Journal of Paediatric Dentistry © 2011 BSPD, IAPD and Blackwell Publishing Ltd.