Picolyl alkyl amines as novel tyrosinase inhibitors: Influence of hydrophobicity and substitution

P Bandyopadhyay, S Jha…

Index: Bandyopadhyay, Punam; Jha, Sujeetkumar; Imran Ali Journal of Agricultural and Food Chemistry, 2009 , vol. 57, # 20 p. 9780 - 9786

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Citation Number: 6

Abstract

Several novel picolyl alkyl amine derivatives (A− L) were synthesized, and the influence of hydrophobicity and substitution on the inhibition of mushroom tyrosinase toward both monophenolase and diphenolase activities are described. α-, β-, and γ-picolyl amines are neither the substrates nor the inhibitors; however, the inhibition is induced by the incorporation of an alkyl chain. The inhibition was strongly dependent on the substitution ...