Design of novel quinazoline derivatives and related analogues as potent and selective ALK5 inhibitors

F Gellibert, MH Fouchet, VL Nguyen, R Wang…

Index: Bioorganic and Medicinal Chemistry Letters, , vol. 19, # 8 p. 2277 - 2281

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Citation Number: 46

Abstract

... Bioorganic & Medicinal Chemistry Letters. ... Having established for this new chemical series that the 6-methyl-pyridin-2-yl group was important not only for the selectivity over p38 but also for ALK5 inhibition, we decided to explore the SAR for the two other heterocycles. ...