Synthesis and biological activity of cinnamaldehydes as angiogenesis inhibitors

…, YK Cho, SH Bok, SH So, MR Youn, SI Chang

Index: Kwon, Byoung-Mog; Lee, Seung-Ho; Cho, Young-Kwon; Bok, Song-Hae; So, Seung-Ho; Youn, Mi-Ran; Chang, Soo-Ik Bioorganic and Medicinal Chemistry Letters, 1997 , vol. 7, # 19 p. 2473 - 2476

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Citation Number: 58

Abstract

A series of 2-hydroxycinnamaldehyde derivatives was synthesized for examing a structure- activity relationship for inhibition of angiogenesis. The anti-angiogenic effects of 2′- substituted cinnamaldehdes and related analogs were determined in a chick embryo chorioallantoic membrane assay system.

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