The first total synthesis of the marine fatty acid (±)-2-methoxy-13-methyltetradecanoic acid: a cytotoxic fatty acid to leukemia cells

NM Carballeira, H Cruz, EA Orellano…

Index: Carballeira, Nestor M.; Cruz, Heidyleen; Orellano, Elsie A.; Gonzalez, Fernando A. Chemistry and Physics of Lipids, 2003 , vol. 126, # 2 p. 149 - 153

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Citation Number: 10

Abstract

The recently discovered marine fatty acid (±)-2-methoxy-13-methyltetradecanoic acid was synthesized for the first time in six steps (26% overall yield) starting from commercially available methyl 12-methyltridecanoate. The synthetic approach provided enough material to corroborate the structure of the acid, which was recently identified in the sponge Amphimedon complanata from Aguadilla, Puerto Rico, and to test its cytotoxicity to three ...