Synthesis and preliminary study of some ring-substituted arylpropanonamines and their quaternary salts

JB Stenlake, GL Patrick, WE Sneader

Index: Stenlake; Patrick; Sneader European Journal of Medicinal Chemistry, 1989 , vol. 24, # 6 p. 591 - 597

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Citation Number: 6

Abstract

Abstract The synthesis and biological examination of 1-phenyl-and 1-(4-bromophenyl)-3-(N- 2-hydroxyethyl-N-methylamino) propan-1-one methiodides and 1-(4-bromophenyl)-3-(N-2- hydroxyethyl-N-methylamino) propan-1-ol methiodide as model potential intravenous anesthetics are described. A series of 1-alkyl-3-aroyl-4-arylpiperidin-4-ols, their mesylate salts and quaternary iodides has been also prepared and examined.