Mild and general one-pot reduction and cyclization of aromatic and heteroaromatic 2-nitroamines to bicyclic 2h-imidazoles
…, BK Chan, AA Estrada, DG Shore, JP Lyssikatos
Index: Hanan, Emily J.; Chan, Bryan K.; Estrada, Anthony A.; Shore, Daniel G.; Lyssikatos, Joseph P. Synlett, 2010 , # 18 p. 2759 - 2764
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Citation Number: 11
Abstract
Abstract A one-pot procedure for the conversion of aromatic and heteroaromatic 2- nitroamines into bicyclic 2H-benzimidazoles is described. The procedure employs formic acid, iron powder, and an additive such as NH 4 Cl to reduce the nitro group and effect the imidazole cyclization with high-yielding conversions generally within one to two hours. The compatibility with a wide range of functionality demonstrates the general utility of this ...
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