Design, synthesis, biological evaluation and computational investigation of novel inhibitors of dihydrofolate reductase of opportunistic pathogens
S Bag, NR Tawari, MS Degani, SF Queener
Index: Bag, Seema; Tawari, Nilesh R.; Degani, Mariam S.; Queener, Sherry F. Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 9 p. 3187 - 3197
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Citation Number: 25
Abstract
The present work deals with design, synthesis and biological evaluation of novel, diverse compounds as potential inhibitors of dihydrofolate reductase (DHFR) from opportunistic microorganisms; Pneumocystis carinii (pc), Toxoplasma gondii (tg) and Mycobacteriumavium (ma). A set of 14 structurally diverse compounds were designed with varying key pharmacophoric features of DHFR inhibitors, bulky distal substitutions and ...
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