de novo design and synthesis of N-benzylanilines as new candidates for VEGFR tyrosine kinase inhibitors.

Masaharu Uno, Hyun Seung Ban, Wataru Nabeyama, Hiroyuki Nakamura

Index: Org. Biomol. Chem. 6(6) , 979-81, (2008)

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Abstract

N-Benzylanilines were designed and synthesized as vascular endothelial growth factor (VEGF)-2 inhibitors using de novo drug design systems based on the X-ray structure of VEGFR-2 kinase domain. Among compounds synthesized, compound showed the most potent inhibitory activity toward VEGFR-2 (KDR) tyrosine kinase and its IC(50) value was 0.57 microM.