4-Phenyl-α-cyanocinnamic acid amide: screening for a negative ion matrix for MALDI-MS imaging of multiple lipid classes

…, B Meyer, S Tambe, R Sandhoff, HD Junker…

Index: Fueloep, Annabelle; Porada, Martina B.; Marsching, Christian; Blott, Henning; Meyer, Bjoern; Tambe, Suparna; Sandhoff, Roger; Junker, Hans-Dieter; Hopf, Carsten Analytical Chemistry, 2013 , vol. 85, # 19 p. 9156 - 9163

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Citation Number: 19

Abstract

Matrix-assisted laser desorption/ionization imaging mass spectrometry (MALDI-IMS) has become a method of choice in lipid analysis, as it provides localization information for defined lipids that is not readily accessible with nonmass spectrometric methods. Most current MALDI matrices have been found empirically. Nevertheless, preferential matrix properties for many analyte classes are poorly understood and may differ between lipid ...