Palladium-catalyzed C− H functionalization of pyridine N-oxides: highly selective alkenylation and direct arylation with unactivated arenes
SH Cho, SJ Hwang, S Chang
Index: Seung, Hwan Cho; Seung, Jun Hwang; Chang, Sukbok Journal of the American Chemical Society, 2008 , vol. 130, # 29 p. 9254 - 9256
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Citation Number: 496
Abstract
Two catalytic protocols of the oxidative C− C bond formation have been developed on the basis of the C− H bond activation of pyridine N-oxides. Pd-catalyzed alkenylation of the N- oxides proceeds with excellent regio-, stereo-, and chemoselectivity, and the corresponding ortho-alkenylated N-oxide derivatives are obtained in good to excellent yields. Direct cross- coupling reaction of pyridine N-oxides with unactivated arene was also developed in the ...
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