Synthesis of novel N-hydroxy heterocycles via intramolecular reductive cyclization of diketoximes by NaBH3CN.
Muthupandi Nagaraj, Muthusamy Boominathan, Shanmugam Muthusubramanian, Nattamai Bhuvanesh
Index: Org. Biomol. Chem. 9 , 4642, (2011)
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Abstract
A simple and efficient protocol for the construction of substituted piperazines, piperidines, thiomorpholines, decahydroquinolines, perhydrocyclopenta[b]pyridine, and pyrrolidines bearing N-hydroxy substituents through intramolecular reductive cyclization of diketoximes using sodium cyanoborohydride is described.
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