Acylphloroglucinol derivatives from Mahurea palustris.

Georges Massiot, Christophe Long, Bruno David, Marie-Jeanne Serrano, Florence Daubié, Frédéric Alby, Frédéric Ausseil, Martine Knibiehler, Christian Moretti, Jean-Sébastien Hoffmann, Christophe Cazaux, Catherine Lavaud

Index: J. Nat. Prod. 68 , 979-84, (2005)

Full Text: HTML

Abstract

Five new acylphloroglucinol derivatives, mahureones A-E (1, 3-6), have been isolated from the leaves of Mahurea palustris, and their structures determined by spectroscopic means. During the isolation process, several byproducts (7-9) were formed by reaction of one of the isoprenyl side chains with TFA, water, and acetonitrile. All the compounds were assayed for their ability to inhibit human DNA polymerase beta. The most active compounds, mahureones A (1) and D (5), exhibited IC50 values in the 10 microM range.