Effective inhibition of viral reproduction by hydrophobised antiviral antibodies.

A V Kabanov, A V Ovcharenko, N S Melik-Nubarov, A I Bannikov, T P Lisok, E V Klyushnenkova, N G Cherchenko, Alakhov VYu, A V Levashov, V I Kiselev

Index: Biomed. Sci. 1(1) , 63-7, (1990)

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Abstract

A method is proposed for the inhibition of viral reproduction in cells by means of fatty-acylated antiviral antibodies which, in contrast to the unmodified antibodies, have the ability to enter the cells. The potential of this technique is demonstrated in experiments involving inhibition of the reproduction of various strains of influenza virus and respiratory syncytial virus.