Journal of Organic Chemistry 2010-08-20

Conjugate addition of lithiated methyl pyridines to enones.

Douglass F Taber, Pengfei Guo, Michael T Pirnot

Index: J. Org. Chem. 75(16) , 5737-9, (2010)

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Abstract

Preparatively useful conjugate addition of lithiated methyl pyridines to cyclic and acyclic enones is reported. Addition of 2-picoline to 3-penten-2-one led to a concise synthesis of the alkaloids (+/-)-senepodine G and (+/-)-cermizine C.

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