Tetrahedron

A convenient route to functionalized 3-amino-N-methylfuro [3, 2-b] pyridine-2-carboxamides

…, MR Nourrisson, P Hautefaye, G De Nanteuil, M Duflos

Index: Breteche, Anne; Marchand, Pascal; Nourrisson, Marie-Renee; Hautefaye, Patrick; De Nanteuil, Guillaume; Duflos, Muriel Tetrahedron, 2011 , vol. 67, # 26 p. 4767 - 4773

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Citation Number: 10

Abstract

Abstract The synthesis of novel functionalized 3-amino-N-methylfuro [3, 2-b] pyridine-2- carboxamides is described from cyanopyridine intermediates. Based on the difference in halogen reactivity, ethyl [(5-bromo-2-chloropyridin-3-yl) oxy] acetate was functionalized by a palladium-catalyzed reaction, before the cyclization to the desired furo [3, 2-b] pyridines.