Synthesis, rotamer orientation, and calcium channel modulation activities of alkyl and 2-phenethyl 1, 4-dihydro-2, 6-dimethyl-3-nitro-4-(3-or 6-substituted-2-pyridyl)-5- …

…, WC Matowe, CA McEwen, MW Wolowyk…

Index: Iqbal, Nadeem; Akula, Murthy R.; Vo, Dean; Matowe, Wandikayi C.; McEwen, Carol-Anne; Wolowyk, Michael W.; Knaus, Edward E. Journal of Medicinal Chemistry, 1998 , vol. 41, # 11 p. 1827 - 1837

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Citation Number: 24

Abstract

A group of racemic alkyl and 2-phenethyl 1, 4-dihydro-2, 6-dimethyl-3-nitro-4-(3-or 6- substituted-2-pyridyl)-5-pyridinecarboxylates (13a-q) was prepared using a modified Hantzsch reaction that involved the condensation of a 3-or 6-substituted-2- pyridinecarboxaldehyde (7a-j) with an alkyl or 2-phenethyl 3-aminocrotonate (11a-d) and nitroacetone (12). Nuclear Overhauser (NOE) studies indicated there is a significant ...