Synthesis, antitumor activity, and antiviral activity of 3-substituted 3-deazacytidines and 3-substituted 3-deazauridines

DJ McNamara, PD Cook, LB Allen…

Index: McNamara, Dennis J.; Cook, P. Dan; Allen, Lois B.; Kehoe, Mary J.; Holland, Carolyn S.; Teepe, Annette G. Journal of Medicinal Chemistry, 1990 , vol. 33, # 7 p. 2006 - 2011

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Citation Number: 16

Abstract

In addition to their reported antitumor activity, 3 and 4 are also reported to display significant activity against a broad spectrum of RNA viruses, including rhinovirus types lA, 13, and 56; influenza A and B; parainfluenza 1 (Sendai); and vesicular stomatis vir~ s.~~~ The target compounds 9a-f as well as the previously synthesized 1, 2, 12, and 13l were therefore also tested for antiviral activity and compared to that of 3 and 4.