Bioorganic & Medicinal Chemistry Letters 2010-09-15

N,O-diacyl-4-benzoyl-N-phenylhydroxylamines as photoinduced DNA cleaving agents.

Nilanjana Chowdhury, Sansa Dutta, Boda Nishitha, Swagata Dasgupta, N D Pradeep Singh

Index: Bioorg. Med. Chem. Lett. 20(18) , 5414-7, (2010)

Full Text: HTML

Abstract

Photoinduced homolytic fission of nitrogen-oxygen bond in N,O-diacyl-4-benzoyl-N-phenylhydroxylamines using 310 nm UV light for 10 min produced acylaminyl and acyloxy radicals, which resulted in single strand cleavage of DNA at pH 7.0. Further the DNA cleaving ability of N,O-diacyl-4-benzoyl-N-phenylhydroxylamines found to depend both on its concentration and acyl substituents.Copyright (c) 2010 Elsevier Ltd. All rights reserved.

Related Compounds

Related Articles:

In situ infrared monitoring of the solid/liquid catalyst interface during the three-phase hydrogenation of nitrobenzene over nanosized Au on TiO2.

2011-07-21

[Phys. Chem. Chem. Phys. 13(27) , 12463-71, (2011)]

Genotoxic activities of aniline and its metabolites and their relationship to the carcinogenicity of aniline in the spleen of rats.

2005-12-01

[Crit. Rev. Toxicol. 35(10) , 783-835, (2005)]

Biotransformation of hydroxylaminobenzene and aminophenol by Pseudomonas putida 2NP8 cells grown in the presence of 3-nitrophenol.

2000-06-01

[Appl. Environ. Microbiol. 66(6) , 2336-42, (2000)]

Superoxide dismutase-mediated reversible conversion of 3-hydroxyamino-1-methyl-5H-pyrido[4,3-b]indole, the N-hydroxy derivative of Trp-P-2, into its nitroso derivative.

1988-11-01

[Carcinogenesis 9(11) , 2003-8, (1988)]

[Phenoxenium ions: generations and reactions].

1994-08-01

[Yakugaku Zasshi 114(8) , 565-76, (1994)]

More Articles...