Pd/Cu-Catalyzed C–H Arylation of 1, 3, 4-Thiadiazoles with (Hetero) aryl Iodides, Bromides, and Triflates

…, A Sharma, E Van der Eycken

Index: Vachhani, Dipak D.; Sharma, Abhishek; Van Der Eycken, Erik Journal of Organic Chemistry, 2012 , vol. 77, # 19 p. 8768 - 8774

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Citation Number: 14

Abstract

The direct C–H arylation of 1, 3, 4-thiadiazoles with a wide range of (hetero) aryl iodides, bromides, and triflates is described using a Pd/Cu-catalyzed protocol. The methodology is compatible with substrates possessing electron-donating or electron-withdrawing substituents and also tolerates sterically hindered aryl halides. The utility of the developed protocol is demonstrated by a one-pot C–H arylation-Suzuki coupling sequence.

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