Oligosaccharides of human milk. Structural studies of two new octasaccharides, difucosyl derivatives of para-lacto-N-hexaose and para-lacto-N-neohexaose.
K Yamashita, Y Tachibana, A Kobata
Index: J. Biol. Chem. 252(15) , 5408-11, (1977)
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Abstract
Two new octasaccharides were isolated from human milk of a nonsecretor Lewis a+b- individual. Structural studies by sequential enzymic degradation and by quantitative methylation analysis revealed that their structures were as follows: Galbeta1 leads to 3 (Fucalpha1 leads to 4) GlcNAcbeta1 leads to 3Galbeta1 leads to 4 (Fucalpha1 leads to 3) GlcNAcbeta1 leads to 3Galbeta1 leads to 4Glc, Galbeta1 leads to 4 (Fucalpha1 leads to 3) GlcNAcbeta1 leads to 3Galbeta1 leads to 4 (Fucalpha1 leads to 3) GlcNAcbeta1 leads to 3Galbeta1 leads to 4Glc. The core portions of these sugars, which are newly found linear hexasaccharides, are named para-lacto-N-hexaose and para-lacto-N-neohexaose, respectively.
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