Bioorganic & Medicinal Chemistry Letters 1999-02-22

(3-substituted benzyl)thiazolidine-2,4-diones as structurally new antihyperglycemic agents.

M Nomura, S Kinoshita, H Satoh, T Maeda, K Murakami, M Tsunoda, H Miyachi, K Awano

Index: Bioorg. Med. Chem. Lett. 9(4) , 533-8, (1999)

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Abstract

A series of 3-[(2,4-dioxothiazolidin-5-yl)methyl]benzamide derivatives was prepared as part of a search for antidiabetic agents. A structure-activity relationship study of these compounds led to the identification of 5-[(2,4-dioxothiazolidin-5-yl)methyl]-2-methoxy-N-[[4-(trifluorome thyl)-phenyl]methyl]benzamide (KRP-297) as a candidate drug for the treatment of diabetes mellitus.