Molecules

Substituted 3-benzylcoumarins as allosteric MEK1 inhibitors: design, synthesis and biological evaluation as antiviral agents

C Wang, H Zhang, F Xu, Y Niu, Y Wu, X Wang, Y Peng…

Index: Molecules, , vol. 18, # 5 p. 6057 - 6091

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Citation Number: 3

Abstract

... Volume. Page. ... Molecules 2013, 18(5), 6057-6091; doi:10.3390/molecules18056057. ... Molecular modeling studies suggested that the best inhibitor, G8935 (Figure 1) with an IC 50 of 0.3 μM, bound to the allosteric site in the unphosphorylated conformation of MEK1. ...