o-Methoxy Derivatives of the Carcinogen, N-2-Fluorenylacetamide. Potential Latent Biological Arylating Agents1

HT Nagasawa, HR Gutmann

Index: Nagasawa,H.T.; Gutmann,H.R. Journal of Medicinal Chemistry, 1966 , vol. 9, p. 719 - 725

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Citation Number: 12

Abstract

The two o-methoxy derivatives of the carcinogen, N-2-fluorenylacetamide, aiz., N-(1- methoxy-2-flrioreny1)-acetamide (1 b) and N-(3-methoxy-2-fluorenyl) acetamide (2b), as well as t, he corresponding amines, l-methoxy-2-fluorenamine (IC) and 3-methoxy-2- flriorenamine (2c), were synthesized starting from indene and indan-1-one, mid tested for carcinogenic activity. The synthetic path leading to the 3-methoxy derivative is amenable ...