The synthesis of Nauclea indole-pyridine alkaloids. 3, 4-Disubstituted and 3, 4, 5-trisubstituted pyridines as synthetic intermediates; a total synthesis of (±)- …

A Shariff, S McLean

Index: Shariff, Azim; McLean, Stewart Canadian Journal of Chemistry, 1983 , vol. 61, p. 2813 - 2820

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Citation Number: 9

Abstract

Synthetic routes to a number of 3, 4-disubstituted and 3, 4, 5-trisubstituted pyridines have been explored. These pyridines, designed to be used in the synthesis of Nauclea indole- pyridine alkaloids, are potentially useful intermediates in a number of syntheses. Particular attention has been paid to more highly substituted derivatives of 4-pyridineacetic acid, and the experimental limitations associated with their synthesis and use in subsequent ...