Bioorganic & medicinal chemistry

Design, synthesis, and antifungal activity of inhibitors of brassilexin detoxification in the plant pathogenic fungus Leptosphaeria maculans

MSC Pedras, M Suchy

Index: Pedras, M. Soledade C.; Suchy, Mojmir Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 3 p. 714 - 723

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Citation Number: 31

Abstract

Potential inhibitors of Leptosphaeria maculans mediated detoxification of the phytoalexin brassilexin were designed and synthesized based on the planar heteroaromatic structure of isothiazolo [5, 4-b] indole. Screening of these compounds for inhibition of brassilexin detoxification in cultures of L. maculans indicated that 4-(2-chlorophenyl) isothiazole had the largest effect on the rate of brassilexin detoxification. However, the most antifungal ...