New dithiolopyrrolone antibiotics from Saccharothrix sp. SA 233. II. Physicochemical properties and structure elucidation.

Lynda Lamari, Abdelghani Zitouni, Tahar Dob, Nasserdine Sabaou, Ahmed Lebrihi, Pierre Germain, Elisabeth Seguin, François Tillequin

Index: J. Antibiot. 55(8) , 702-6, (2002)

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Abstract

Three new natural dithiopyrrolone antibiotics, 3-methyl-2-butenoylpyrrothine (1), tigloylpyrrothine (2), and n-butyropyrrothine (3) were isolated along with the known isobutyropyrrothine (4) and thiolutin (5) from the fermentation broth of Saccharothrix sp. SA 233. The structures of the novel compounds were established on the basis on their spectral data.