Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine / Zhongguo Zhong xi yi jie he xue hui, Zhongguo Zhong yi yan jiu yuan zhu ban 1996-12-01

[Inhibitory effects of co-cinobufotalin oral liquor on hepatitis B in vitro].

Z Liu, X X Fu, N L Zhang

Index: Zhongguo Zhong Xi Yi Jie He Za Zhi 16(12) , 738-40, (1996)

Full Text: HTML

Abstract

Co-Cinobufotalin Oral Liquor (CCOL) was studied for its ability to inhibit hepatitis B virus DNA replication, HBsAg and HBeAg expression in a HBV-transfected cell line (2.2.15 cell). The result showed that ID50 (the drug concentration that inhibits HBsAg or HBeAg secretion by 50%) was 0.08 mg/ml and 0.07 mg/ml on HBsAg and HBeAg respectively. CD50 (the drug concentration that reduces cell growth by 50%) was 2.5 mg/ml. TI (therapeutic index) was 31.3 and 35.7 respectively. The present data suggest that CCOL could exert a potent antiviral activity against HBV in vitro. Southern blot showed that CCOL inhibited HBV-DNA repication in a dose-dependent manner.

Related Compounds

Related Articles:

Pre-clinical evaluation of cinobufotalin as a potential anti-lung cancer agent.

2014-09-26

[Biochem. Biophys. Res. Commun. 452(3) , 768-74, (2014)]

Ceramide production mediates cinobufotalin-induced growth inhibition and apoptosis in cultured hepatocellular carcinoma cells.

2015-08-01

[Tumour Biol. 36 , 5763-71, (2015)]

Comparative Analysis of the Bufonis Venenum by Using TLC, HPLC, and LC-MS for Different Extraction Methods.

2012-12-01

[J Pharmacopuncture 15 , 52-65, (2015)]

Chemical defense of an Asian snake reflects local availability of toxic prey and hatchling diet.

2013-04-01

[J. Zool. (Lond.) 289 , 270-278, (2013)]

[Clinical study on cinobufotalin in treating chronic hepatitis B virus carriers].

1993-08-01

[Zhongguo Zhong Xi Yi Jie He Za Zhi 13(8) , 473-5, 453-4, (1993)]

More Articles...