Phosphoramidates: features of the formation mechanism and the relationship structure-bioaction

VI Krutikov, AV Erkin, VV Krutikova

Index: Krutikov; Erkin; Krutikova Russian Journal of General Chemistry, 2012 , vol. 82, # 5 p. 822 - 826

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Citation Number: 10

Abstract

Abstract Mechanism of the synthesis of phosphoramidates by Todd-Atherton reaction is based on the primary interaction of a polyhaloalkane with the highly basic amine to form a 1: 1 associate. The subsequent attack by the associate on the hydrophosphoryl compound of “symmetric” structure leads to the formation of the target compounds in high yields. The test of the effect of dialkyl hexamethylene-and dialkyl (pyridin-2-yl)-phosphoramidates in vitro ...