Lumazine peptides penilumamides B-D and the cyclic pentapeptide asperpeptide A from a gorgonian-derived Aspergillus sp. fungus.

Min Chen, Chang-Lun Shao, Xiu-Mei Fu, Chui-Jian Kong, Zhi-Gang She, Chang-Yun Wang

Index: J. Nat. Prod. 77(7) , 1601-6, (2014)

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Abstract

Three new lumazine peptides, penilumamides B-D (2-4), and one known analogue, penilumamide (1), together with a new cyclic pentapeptide, asperpeptide A (5), were isolated from the gorgonian-derived fungus Aspergillus sp. XS-20090B15. Among them, 2 was obtained from the feeding culture with l-methionine of this strain. All structures were elucidated by spectroscopic methods and chemical derivatization. Compounds 1-4 are rare lumazine peptides, of which 1 and 3 are formed from 2 by oxidation of the l-methionine residue.