Highly Selective Trifluoromethylation of 1, 3??Disubstituted Arenes through Iridium??Catalyzed Arene Borylation

T Liu, X Shao, Y Wu, Q Shen

Index: Liu, Tianfei; Shao, Xinxin; Wu, Yaming; Shen, Qilong Angewandte Chemie - International Edition, 2012 , vol. 51, # 2 p. 540 - 543

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Citation Number: 146

Abstract

The trifluoromethyl group has evolved into an indispensable structural motif [1] for the pharmaceutical industry because of its unique size, electronic properties, and excellent metabolic stability, as evidenced by a large number of trifluoromethylated pharmaceuticals and drug candidates, such as the antidepressant Prozac,[2] the fungicide Trifloxystrobin,[3] and the herbicide Fusilade.[4] Consequently, development of new and efficient methods to ...