A potent new class of. kappa.-receptor agonist: 4-substituted 1-(arylacetyl)-2-[(dialkylamino) methyl] piperazines

A Naylor, DB Judd, JE Lloyd, DIC Scopes…

Index: Naylor; Judd; Lloyd; Scopes; Hayes; Birch Journal of Medicinal Chemistry, 1993 , vol. 36, # 15 p. 2075 - 2083

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Citation Number: 87

Abstract

The synthesis of 4-substituted l-(arylacetyl)-2-[(alkylamino) methyllpiperazines (10-22, 26, 27, and 30-33) and their activities as K-opioid receptor agonists are described. This includes a range of 4-acyl and 4-carboalkoxy derivatives with the latter series showing the greatest K- agonist activity.