MONNA, a potent and selective blocker for transmembrane protein with unknown function 16/anoctamin-1

…, J Jung, K Yu, J Kim, JY Choi, HC Hartzell, EJ Roh…

Index: Oh, Soo-Jin; Hwang, Seok Jin; Jung, Jonghoon; Yu, Kuai; Kim, Jeongyeon; Choi, Jung Yoon; Hartzell, H. Criss; Roh, Eun Joo; Justin Lee Molecular Pharmacology, 2013 , vol. 84, # 5 p. 726 - 735

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Citation Number: 20

Abstract

Abstract Transmembrane protein with unknown function 16/anoctamin-1 (ANO1) is a protein widely expressed in mammalian tissues, and it has the properties of the classic calcium- activated chloride channel (CaCC). This protein has been implicated in numerous major physiological functions. However, the lack of effective and selective blockers has hindered a detailed study of the physiological functions of this channel. In this study, we have ...