A facile synthesis of new 5H-indazolo[3,2-b]benzo[d]-1,3-oxazines via one-pot intramolecular Bis-heterocyclizations.
Jeffrey D Butler, Danielle M Solano, Lori I Robins, Makhluf J Haddadin, Mark J Kurth
Index: J. Org. Chem. 73(1) , 234-40, (2008)
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Abstract
The parent 5H-indazolo[3,2-b]benzo[d]-1,3-oxazine heterocycle as well as a series of novel analogues have been synthesized utilizing two subsequent intramolecular heterocyclizations in one pot. A variety of diversity groups were added to explore the scope of this reaction and to provide a number of new compounds for biological screening.
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