Effect of carbonates/phosphates as nucleophilic catalysts in dimethylformamide for efficient cyanosilylation of aldehydes and ketones.

G K Surya Prakash, Habiba Vaghoo, Chiradeep Panja, Vijayalakshmi Surampudi, Roman Kultyshev, Thomas Mathew, George A Olah

Index: Proc. Natl. Acad. Sci. U. S. A. 104(9) , 3026-30, (2007)

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Abstract

Cyanosilylation of aldehydes and aliphatic ketones can be carried out in dimethylformamide even without the use of any catalyst. In the presence of nucleophilic catalysts such as carbonate and phosphate salts, the reaction rate is significantly enhanced.