Enantioselective syntheses of trans-3, 4-difluoropyrrolidines and investigation of their applications in catalytic asymmetric synthesis

CM Marson, RC Melling

Index: Shellhamer, Dale F.; Anstine, D. Timothy; Gallego, Kelly M.; Ganesh, Brian R.; Hanson, Aaron A.; et al. Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1995 , # 4 p. 861 - 866

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Citation Number: 23

Abstract

... in the cases of 4a (R = n-octyl) and 4c (R = Ph), but 4b (R = cyclohexyl) decomposed ... THF at reflux afforded the benzyl derivative 10b (82%) which was deprotected with 10 M hydrochloric acid ... in which induction depends on asymmetry derived from assembly around a C−F bond ...