An efficient method for the N-arylation of phenylurea via copper catalyzed amidation
…, MS Mane, PN Pabrekar, MS Shingare, DV Mane
Index: Gavade, Sandip N.; Balaskar, Ravi S.; Mane, Madhav S.; Pabrekar, Pramod N.; Shingare, Murlidhar S.; Mane, Dhananjay V. Chinese Chemical Letters, 2011 , vol. 22, # 6 p. 675 - 678
Full Text: HTML
Citation Number: 6
Abstract
Abstract The coupling reaction of phenylurea with different functionalized aryl halides in the presence of air stable CuI, N, N-dimethylethylenediamine as a ligand, and K 3 PO 4 as a base gives symmetrical and unsymmetrical diarylureas in relatively high yields. This method is milder than the palladium catalyzed arylation and avoids the use of toxic phosphine ligands.
Related Articles:
[Yadav, Deepak K.; Yadav, Arvind K.; Srivastava, Vishnu P.; Watal, Geeta; Yadav, Lal Dhar S. Tetrahedron Letters, 2012 , vol. 53, # 23 p. 2890 - 2893]
[Gavade, Sandip; Shingare, Murlidhar; Mane, Dhananjay Bulletin of the Korean Chemical Society, 2011 , vol. 32, # 12 p. 4167 - 4170]
Palladium-catalyzed reaction of aryl halides with ureas
[Artamkina, Galina A.; Sergeev, Alexey G.; Beletskaya, Irina P. Tetrahedron Letters, 2001 , vol. 42, # 26 p. 4381 - 4384]
In Silico Exploration for New Antimalarials: Arylsulfonyloxy Acetimidamides as Prospective Agents
[Lin, Chia-Chi; Hsieh, Tsung-Han; Liao, Pen-Yuan; Liao, Zhen-Yuan; Chang, Chih-Wei; Shih, Yu-Chiao; Yeh, Wen-Hsiung; Chien, Tun-Cheng Organic Letters, 2014 , vol. 16, # 3 p. 892 - 895]
Cu (acac) 2-Catalyzed N-Arylations of Phenylurea with Aryl Boronic Acid
[Gavade, Sandip; Balaskar, Ravi; Mane, Madhav; Pabrekar, Pramod N.; Mane, Dhananjay Synthetic Communications, 2012 , vol. 42, # 11 p. 1704 - 1714]